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6. Meryl Streep, actor
7. Peter Rice, president of Fox Searchlight
8. Tyler Perry, actor/director/writer/producer
9. David Heyman, producer
10. John Knoll, visual-effects supervisor of Industrial Light & Magic
11. Brian Grazer, producer
12. Dick Cook, chairman of the Walt Disney Studios
13. George Clooney, actor/director/producer
14. Jerry Bruckheimer, producer
15. Amy Pascal, co-chairman of Sony Pictures Entertainment
16. Peter Jackson, director/producer
17. Will Ferrell, actor/producer
18. Robert Zemeckis, director
19. Tom Rothman, co-chair of Fox Filmed Entertainment
20. Ben Stiller, actor/director/producer
21. Johnny Depp, actor/producer
22. Jeffrey Katzenberg, CEO of DreamWorks Animation
23. Brad Bird, writer/director
24. Emmanuel Lubezki, cinematographer
25. Zack Snyder, director
26. Stacey Snider, CEO of DreamWorks SKG
27. Michael Moore, documentarian
28. Paul Greengrass, director
29. J.J. Abrams, producer/director
30. Jodie Foster, actor/director
31. Kathleen Kennedy, producer
32. Thelma Schoonmaker, editor
33. Angelina Jolie, actor
34. Sacha Baron Cohen, actor/writer/producer
35. Tim Palen, co-president of film marketing for Lionsgate
36. Modi Wiczyk, co-CEO of Media Rights Capital
37. Guillermo del Toro, writer/producer/director
38. Diablo Cody, screenwriter
39. Mary Zophres, costume designer
40. Jeff Skoll, founder of Participant Productions
41. Stefan Sonnenfeld, president of Company 3
42. Daniel Battsek, president of Miramax Films
43. Beth Swofford, agent at CAA
44. Roderick Jaynes, editor
45. Cate Blanchett, actor
46. Jeff Walker, Comic-Con impresario
47. Amy Powell, senior vice president of interactive marketing at Paramount
48. Gustavo Santaolalla, composer
49. Sarah Polley, actor/writer/director
50. Ben Affleck, actor/director/writer/producer

Source: The 50 Smartest People in Hollywood [ EW]

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